The synergistic action of ethanol and nerve growth factor in the induction of neuronal nitric oxide synthase Article

Phung, YT, Black, SM. (1999). The synergistic action of ethanol and nerve growth factor in the induction of neuronal nitric oxide synthase . 34(4), 506-510. 10.1093/alcalc/34.4.506

cited authors

  • Phung, YT; Black, SM

fiu authors

abstract

  • Ethanol alone had no effect on neuronal nitric oxide synthase (nNOS) expression in PC12 cells. However, in the presence of nerve growth factor (NGF), nNOS expression was amplified (threefold, P < 0.05), compared to NGF alone. This increase was eliminated with pretreatment of PC12 cells with staurosporine, suggesting that the effects of ethanol on nNOS expression are mediated by a protein kinase C-dependent pathway.

publication date

  • August 17, 1999

Digital Object Identifier (DOI)

start page

  • 506

end page

  • 510

volume

  • 34

issue

  • 4