Preimplantation Diagnosis and Other Modern Methods for Prenatal Diagnosis

Preimplantation Diagnosis and Other Modern Methods for Prenatal Diagnosis Book Chapter

Simpson, JL. (2014). Preimplantation Diagnosis and Other Modern Methods for Prenatal Diagnosis . 343-350. 10.1016/B978-0-12-416006-4.00028-4

In the late 1980s chorionic villus sampling (CVS) became available, permitting first trimester diagnosis. Now, maternal administration of dexamethasone to prevent genital virilization can be restricted to pregnancies with affected female fetuses earlier in gestation. If the fetus were male, affected with CAH or not, treatment could cease, and would be resumed after birth if the neonate proved to be affected. Although CVS could safely be performed at 10 weeks' gestation, treatment still had to begin before fetal gender and genotype was known. © 2014 Elsevier Inc. All rights reserved.