Preimplantation genetic diagnosis to improve pregnancy outcomes in subfertility

Preimplantation genetic diagnosis to improve pregnancy outcomes in subfertility Article

Simpson, JL. (2012). Preimplantation genetic diagnosis to improve pregnancy outcomes in subfertility . 26(6), 805-815. 10.1016/j.bpobgyn.2012.05.009

Pre-implantation genetic diagnosis provides prenatal genetic diagnosis before implantation, thus allowing detection of chromosomal abnormalities and their exclusion from embryo transfer in assisted reproductive technologies. Polar body, blastomere or trophectoderm can each be used to obtain requisite genetic or embryonic DNA. Pre-implantation genetic diagnosis for excluding unbalanced translocations is well accepted, and pre-implantation genetic diagnosis aneuploidy testing to avoid repeated pregnancy losses in couples having recurrent aneuploidy is efficacious in reducing miscarriages. Controversy remains about whether pre-implantation genetic diagnosis aneuploidy testing improves take home pregnancy rates, for which reason adherence to specific indications is recommended while the issue is being adjudicated. Current recommendations are for obligatory 24 chromosome testing, most readily using array comparative genome hybridisation. © 2012 Elsevier Ltd. All rights reserved.