Genetically determined sex-reversal in 46,XY humans Article

German, J, Simpson, JL, Chaganti, RSK et al. (1978). Genetically determined sex-reversal in 46,XY humans . 202(4363), 53-56. 10.1126/science.567843



cited authors

  • German, J; Simpson, JL; Chaganti, RSK; Summitt, RL; Reid, LB; Merkatz, IR

fiu authors

abstract

  • Evidence is presented for the existence of a gene, probably on the X chromosome, which prevents testis differentiation when present in 46,XY human embryos. Affected 46,XY women are not completely normal because of premature ovarian involution, as a result of which they have "streak gonads" similar to those of 45,X women.

publication date

  • January 1, 1978

Digital Object Identifier (DOI)

start page

  • 53

end page

  • 56

volume

  • 202

issue

  • 4363