Lack of heritability in ovarian germ cell malignancies Article

cited authors

  • Shulman, LP; Muram, D; Marina, N; Jones, C; Portera, JC; Wachtel, SS; Simpson, JL; Elias, S

fiu authors

abstract

  • OBJECTIVE: Our purpose was to determine whether relatives of patients with ovarian germ cell malignancies not associated with sex chromosome abnormalities are at increased risk for similar tumors. STUDY DESIGN: We reviewed pedigrees of 78 presumptive 46,XX patients (ages ranging from newborn to 20 years) with malignant ovarian germ cell tumors, excluding cases of dysgerminoma and gonadoblastoma. A three-generation family history of each proband was reviewed specifically to identify cancer in any family member. RESULTS: Seventy-eight mothers, 87 sisters, 135 aunts, and 156 grandmothers were surveyed. None had a malignant ovarian germ cell neoplasm or other malignant ovarian neoplasm. CONCLUSION: First- and second-degree relatives of probands with ovarian germ cell malignancies do not have an increased risk for similar tumors. These findings were not predicted because of the well-recognized association of hereditary tumors and early age of onset. (AM J Obstet Gynecol 1994;170:1803-8.) © 1994, Mosby, Inc.. All rights reserved.

publication date

  • January 1, 1994

Digital Object Identifier (DOI)

start page

  • 1803

end page

  • 1808

volume

  • 170

issue

  • 6