Preimplantation genetic diagnosis reduces pregnancy loss in women aged 35 years and older with a history of recurrent miscarriages Article

Munné, S, Chen, S, Fischer, J et al. (2005). Preimplantation genetic diagnosis reduces pregnancy loss in women aged 35 years and older with a history of recurrent miscarriages . 84(2), 331-335. 10.1016/j.fertnstert.2005.02.027



cited authors

  • Munné, S; Chen, S; Fischer, J; Colls, P; Zheng, X; Stevens, J; Escudero, T; Oter, M; Schoolcraft, B; Simpson, JL; Cohen, J

fiu authors

abstract

  • Objective: To determine whether preimplantation genetic diagnosis (PGD) and transfer of euploid embryos would decrease spontaneous abortion rates in recurrent miscarriage (RM) patients. Design: Controlled clinical study. Setting: In vitro fertilization centers and PGD reference laboratory. Patient(s): Recurrent-miscarriage patients with three or more prior lost pregnancies with no known etiology. Intervention(s): Biopsy of a single blastomere from each day 3 embryo, followed by fluorescence in situ hybridization analysis. Main Outcome Measure(s): The rate of spontaneous abortions in RM subjects undergoing PGD were compared with [1] their own a priori expectations and [2] a comparison group of women undergoing PGD for advanced maternal age (≥35 years). Result(s): Before PGD, RM patients had lost 87% (262/301) of their pregnancies, with an expected loss rate of 36.5%. After, they only lost 16.7% pregnancies. This difference was mostly due to reduction in pregnancy loss in the ≥35-years age subgroup, to 12% from an expected 44.5%. Conclusion(s): Preimplantation genetic diagnosis aneuploidy screening has a beneficial effect on pregnancy outcome in RM couples, especially those in which the woman is aged ≥35 years. Our data indicate that PGD reduces the risk of miscarriage in RM patients to baseline levels. ©2005 by American Society for Reproductive Medicine.

publication date

  • August 1, 2005

Digital Object Identifier (DOI)

start page

  • 331

end page

  • 335

volume

  • 84

issue

  • 2