Genetics of endometriosis: Heritability and candidate genes Article

Bischoff, F, Simpson, JL. (2004). Genetics of endometriosis: Heritability and candidate genes . 18(2), 219-232. 10.1016/j.bpobgyn.2004.01.004

cited authors

  • Bischoff, F; Simpson, JL

fiu authors


  • Endometriosis is a complex gynecologic disorder that affects as many as 10-15% of premenopausal women. Epidemiologic studies have confirmed that this disease is a genetic disorder of polygenic/multifactorial inheritance. The disorder has long been recognized to show heritable tendencies with recurrence risks of 5-7% for first-degree relatives. The current investigational goal is to determine the number and location of causative genes, a process that has been made possible by recent advances in molecular technology. This chapter discusses heritability studies supporting polygenic/multifactorial inheritance, the scientific basis of genome-wide strategies for identifying causative genes and potential candidate genes. © 2004 Elsevier Ltd. All rights reserved.

publication date

  • January 1, 2004

Digital Object Identifier (DOI)

start page

  • 219

end page

  • 232


  • 18


  • 2