Genetics studies in incomplete mullerian fusion Article

cited authors

  • Elias, S; Simpson, JL; Carson, SA; Malinak, LR; Buttram, VC

fiu authors

abstract

  • No formal genetic studies of incomplete mullerian fusion anomalies have been conducted previously, despite several reports of familial aggregates. Accordingly, the authors sought to determine the frequency with which symptomatic mullerian fusion anomalies occurred in relatives of a small but genetically unbiased sample of 24 probands. Only one of 37 (2.7%) female sibs over age 16 appeared to have a symptomatic uterine anomaly; none of 24 mothers, none of 45 maternal aunts, and none of 50 paternal aunts appeared affected. Such a low frequency of affected relatives is more consistent with polygenic/multifactorial etiology than with other genetic etiologies. © 1984 by The American College of Obstetricians and Gynecologists.

publication date

  • January 1, 1984

start page

  • 276

end page

  • 279

volume

  • 63

issue

  • 3