Localization of the nucleolar organizer by computer-aided analysis of a variant no. 21 in a human isolate Article

cited authors

  • Martin, AO; Miller, L; Simpson, JL; Thomas, C; Rzeszotarski, MS; Elias, S; Sarto, GE; Patel, VA

fiu authors

abstract

  • A variant chromosome no. 21 consisting of two stalks and two satellites in tandem was detected during a survey of a human isolate. The variant segregated in three generations of a large kindred. One male had the variant no. 21, a metacentric Y, and a 47, XXY complement; however, no other evidence of chromosomal nondisjunction was found. Computer-aided analysis of sequentially stained variant no. 21 chromosomes indicated that silver-stained material corresponded to the proximal stalk region (as defined defined by Giemsa). These data support the hypothesis that human nucleolar organizers are localized to the stalks of acrocentric chromosomes. © 1979 Springer-Verlag.

publication date

  • January 1, 1979

Digital Object Identifier (DOI)

start page

  • 211

end page

  • 219

volume

  • 48

issue

  • 2