Linkage analysis in von Willebrand disease Article

Verp, MS, Radvany, RM, Green, D et al. (1983). Linkage analysis in von Willebrand disease . 24(6), 434-438. 10.1111/j.1399-0004.1983.tb00099.x



cited authors

  • Verp, MS; Radvany, RM; Green, D; Conneally, PM; Patel, VA; Martin, AO; Simpson, JL

fiu authors

abstract

  • We studied a 3‐generation kindred to determine whether the gene responsible for one form of von Willebrand disease (vWD) is linked to 1) the HLA locus, or 2) a polymorphic locus for a serum enzyme or red cell antigen. HLA haplotypes were determined in 12 affected family members, in 10 cases by direct analysis and in 2 cases by deduction. Seven of 12 affected individuals were A2, B7, as compared to 0 of 9 unaffected. However, the maximum lod score was only 0.41 at a recombination frequency of 0.2. Of the 17 serum red cell and plasma protein markers studied, 5 (Kell, ADA, AK1, BF, GC) did not segregate, and 12 (ABO, Rh, JK, Fy, P, PGM1, ACPI, ESD, GLOl, MN, HP, GPT) gave lod scores less than +1.0. We conclude that there is no strong evidence for linkage between the locus for vWD and any of the markers studied. Copyright © 1983, Wiley Blackwell. All rights reserved

publication date

  • January 1, 1983

Digital Object Identifier (DOI)

start page

  • 434

end page

  • 438

volume

  • 24

issue

  • 6