Heritable aspects of endometriosis. II. Clinical characteristics of familial endometriosis Article

Malinak, LR, Buttram, VC, Elias, S et al. (1980). Heritable aspects of endometriosis. II. Clinical characteristics of familial endometriosis . 137(3), 332-337. 10.1016/0002-9378(80)90918-7



cited authors

  • Malinak, LR; Buttram, VC; Elias, S; Simpson, JL

fiu authors

abstract

  • Clinical characteristics of patients with histologically confirmed pelvic endometriosis who had an affected first-degree relative (N = 18) were compared to those who had no such affected relative (N = 105). The only significant difference was that 61% of individuals in the former group had severe endometriosis, compared to only 24% in the latter group. This observation is most consistent with a polygenic/multifactorial etiology, although other genetic mechanisms cannot be excluded. Our observations carry several important practical implications. First, an apparently unaffected patient with an affected first-degree relative should be counseled that her risk of developing endometriosis is 7%. This might influence the choice of contraception, the timing of pregnancy, and the extent to which aggressive diagnostic approaches (e.g., laparoscopy and curettage) would be appropriate. © 1980.

publication date

  • June 1, 1980

Digital Object Identifier (DOI)

start page

  • 332

end page

  • 337

volume

  • 137

issue

  • 3