Heritability and candidate genes for endometriosis Article

Simpson, JL, Bischoff, F. (2003). Heritability and candidate genes for endometriosis . 7(2), 162-169. 10.1016/S1472-6483(10)61746-4

cited authors

  • Simpson, JL; Bischoff, F

fiu authors


  • Endometriosis is inherited in polygenic/multifactorial fashion, with recurrence risks of 5-7% for first-degree relatives. The current task is to determine the number and location of causative genes. This review initially supports the basis for polygenic/multifactorial inheritance and then outlines genome-wide strategies for identifying causative genes. Potential candidate genes are surveyed, and discrepant results emphasized. Finally, a hypothesis for endometriosis, having a multi-step pathogenesis analogous to the pathogenesis of neoplasia, is considered.

publication date

  • January 1, 2003

Digital Object Identifier (DOI)

start page

  • 162

end page

  • 169


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