Translocations are infrequent among couples having repeated spontanous abortions but no other abnormal pregnancies Article

Simpson, JL, Meyers, CM, Martin, AO et al. (1989). Translocations are infrequent among couples having repeated spontanous abortions but no other abnormal pregnancies . 51(5), 811-814. 10.1016/s0015-0282(16)60671-4

cited authors

  • Simpson, JL; Meyers, CM; Martin, AO; Elias, S; Ober, C

fiu authors

abstract

  • During the years 1977 to 1986, cytogenetic studies were performed on 342 women and 297 men whose reproductive history included one or more first trimester spontaneous abortions. Thirty-nine women and 35 men experienced not only early fetal losses but also one or more stillborn infants, liveborn anomalous infants, or early neonatal deaths. Among the 303 women and 262 men evaluated solely because of repetitive abortions, only 1 woman and 1 man showed a translocation. Two translocations were detected among the 39 women and 35 men having not only repetitive abortions but also a stillborn infant, anomalous liveborn, or unexplained neonatal death. Only among the 25 women having abortions and other abnormal perinatal events was the frequency of translocations high (2/25 or 8%). Our data continue to indicate that balanced chromosomal translocations are relatively infrequent in individuals having repeated abortions but no other adverse perinatal outcome.

publication date

  • January 1, 1989

Digital Object Identifier (DOI)

start page

  • 811

end page

  • 814

volume

  • 51

issue

  • 5