Drug Ingestion During Pregnancy: Infrequent Exposure in a Contemporary United States Sample Article

Simpson, JL, Morey, A, Metzger, BE et al. (1989). Drug Ingestion During Pregnancy: Infrequent Exposure in a Contemporary United States Sample . 6(2), 244-251. 10.1055/s-2007-999586

cited authors

  • Simpson, JL; Morey, A; Metzger, BE; Brown, Z; Van Allen, M; Elias, S; Mills, JL; Aarons, JH; Knopp, RH; Holmes, LB; Jovanovic-Peterson, L

fiu authors

abstract

  • Drug ingestion in a cohort of United States women proved consistently lower than in prior United States populations. Participating were 342 insulin-dependent diabetic and 387 control subjects who were enrolled before conception (76%) or no later than 21 days after conception (24%). Drug exposures were then recorded at entry and periodically throughout organogenesis (gestational weeks 6, 8,10). During gestational weeks 1 to 10, approximately two thirds of the subjects were exposed to no agent other than oral iron, oral vitamins, or insulin (diabetic subjects). The mean exposures in gestational weeks 1 to 10 were 0.72 ± 1.05 (SD) for diabetic women and 0.54 ± 0.96 for control subjects; throughout pregnancy, the mean exposures were 1.26 ± 1.66 and 1.58 ± 1.78, respectively. The low exposure frequency in this contemporary United States population is highly encouraging. However, it follows that collaborative cohort efforts may be necessary in order to assess teratogenicity of drugs because relatively few women are now exposed. © 1989, by Thieme Medical Publishers, Inc. All rights reserved.

publication date

  • January 1, 1989

Digital Object Identifier (DOI)

start page

  • 244

end page

  • 251

volume

  • 6

issue

  • 2