Fetomaternal transfusion depends on amount of chorionic villi aspirated but not on method of chorionic villus sampling Article

cited authors

  • Shulman, LP; Meyers, CM; Simpson, JL; Andersen, RN; Tolley, EA; Elias, S

fiu authors


  • Transcervical and transabdominal chorionic villus sampling are believed, on the basis of indirect evidence, to result in fetomaternal transfusion. We sought to measure this phenomenon by devising a simple method that would allow us to identify variables that influence fetomaternal transfusion. We investigated patients undergoing transcervical-chorionic villus sampling (n = 15) and transabdominal-chorionic villus sampling (n = 15), restricting the sample to subjects who required only a single catheter passage or needle insertion to obtain villi. Maternal serum α-fetoprotein was measured before and after the procedure along with α-fetoprotein concentration of the transport medium into which the villi had been aspirated. We first confirmed that the change in maternal serum α-fetoprotein levels after chorionic villus sampling, an indirect measure of fetomaternal transfusion, was indeed correlated with the α-fetoprotein concentration of transport medium into which the villi were aspirated (p = 0.0350). Fetomaternal transfusion next proved to be correlated with the amount of villi obtained (p = 0.0279). However, when adjusted for the amount of villi obtained, no significant difference was observed between transcervical and transabdominal-chorionic villus sampling with respect to the change in maternal serum α-fetoprotein levels after chorionic villus sampling (p = 0.8512). These data suggest that the magnitude of fetomaternal transfusion depends on the amount of villi obtained but not on the chorionic villus sampling method used. © 1990.

publication date

  • January 1, 1990

Digital Object Identifier (DOI)

start page

  • 1185

end page

  • 1188


  • 162


  • 5