Vitamins, folic acid and neural tube defects: Comments on investigations in the United States Article

Simpson, JL, Mills, JL, Rhoads, GG et al. (1991). Vitamins, folic acid and neural tube defects: Comments on investigations in the United States . 11(8), 641-648. 10.1002/pd.1970110823



cited authors

  • Simpson, JL; Mills, JL; Rhoads, GG; Cunningham, GC; Hoffman, HJ; Conley, MR

fiu authors

abstract

  • No clear answer concerning whether multivitamin/folate supplementation prevents neural tube defects (NTDs) is provided by three studies in the United States. All these studies are occurrence in nature, no recurrence studies having been conducted. The Atlanta Birth Defects Study is subject to pronounced memory and recall biases, the length between event and interview being as long as 16 years. In a second study (Boston University), objections can be raised to certain aspects of the experimental design, and the claim that 22 per cent of women started vitamins sufficiently early after pregnancy diagnosis to influence NTD formation is suspicious. Our NICHD case control study of 541 women in California and Illinois revealed no evidence for multivitamins or folic acid preventing NTDs. U.S. public policy‐makers face difficulties in applying results of recurrence or occurrence studies in high‐risk areas to low‐risk areas in the U.S. Copyright © 1991 John Wiley & Sons, Ltd.

publication date

  • January 1, 1991

Digital Object Identifier (DOI)

start page

  • 641

end page

  • 648

volume

  • 11

issue

  • 8