Pregnancy-associated plasma protein A, free β-hCG, nuchal translucency, and risk of pregnancy loss Article

Goetzl, L, Krantz, D, Simpson, JL et al. (2004). Pregnancy-associated plasma protein A, free β-hCG, nuchal translucency, and risk of pregnancy loss . 104(1), 30-36. 10.1097/01.AOG.0000129969.78308.4f

cited authors

  • Goetzl, L; Krantz, D; Simpson, JL; Silver, RK; Zachary, JM; Pergament, E; Platt, LD; Mahoney, MJ; Wapner, RJ

fiu authors


  • OBJECTIVE: To estimate the likelihood of clinical early and late pregnancy loss as a function of first-trimester maternal serum analytes and fetal nuchal translucency measurements. METHODS: Study subjects were recruited for a National Institute of Child Health and Human Development-sponsored multicenter cohort study initially designed to study the detection of Down syndrome during the first trimester of pregnancy. The cohort consisted of women who had a live fetus between 10 and 14 weeks of gestation and had no significant vaginal bleeding. Women with prior fetal trisomy (T21/18) and those with structural or chromosomal abnormalities in the index pregnancy were excluded. First-trimester screening consisted of pregnancy-associated plasma protein A (PAPP-A), free β-hCG, and nuchal translucency. Pregnancy loss rates in women with various levels of PAPP-A, free β-hCG, or nuchal translucency (less than 1st, less than 5th, more than 95th, and more than 99th percentile) were compared with losses in women with normal values (5th to 95th percentile). RESULTS: The mean gestational age at screening of 7,932 women meeting study criteria was 12.1 weeks. Loss rates were only 0.36% at less than 20 weeks after normal free β-hCG, PAPP-A, and nuchal translucency. Conversely, low levels of PAPP-A and free β-hCG as well as increased nuchal translucency were individually associated with increased early loss. These associations persisted after controlling for maternal age and race using logistic regression analysis. CONCLUSION: Normal values of PAPP-A, free β-hCG, and nuchal translucency are associated with a very low risk of pregnancy loss at less than 20 weeks. © 2004 by The American College of Obstetricians and Gynecologists.

publication date

  • July 1, 2004

Digital Object Identifier (DOI)

start page

  • 30

end page

  • 36


  • 104


  • 1