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Genetic basis of endometriosis
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Bischoff, F, Simpson, JL. (2004). Genetic basis of endometriosis .
1034 284-299. 10.1196/annals.1335.030
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Bischoff, F, Simpson, JL. (2004). Genetic basis of endometriosis .
1034 284-299. 10.1196/annals.1335.030
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cited authors
Bischoff, F; Simpson, JL
fiu authors
Leigh Simpson, Joe
abstract
Endometriosis is a complex gynecologic disorder that has long been recognized as showing heritable tendencies, with recurrence risks of 5-7% for first-degree relatives. Familial and epidemiologic studies support that this disease is a genetic disorder of polygenic/multifactorial inheritance. The current investigational challenge is to determine the number and location of causative genes. Recent advances in molecular technology make identification and elucidation of these genes now possible. In this review, we update previous communications in which we also reviewed heritability studies supporting polygenic/multifactorial inheritance, discuss the scientific basis of genomewide strategies for identifying causative genes, and identify potential candidate genes. © 2004 New York Academy of Sciences.
publication date
January 1, 2004
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Digital Object Identifier (DOI)
https://doi.org/10.1196/annals.1335.030
Additional Document Info
start page
284
end page
299
volume
1034