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The genetics of polycystic ovary syndrome
Article
Amato, P, Simpson, JL. (2004). The genetics of polycystic ovary syndrome .
18(5 SPEC. ISS.), 707-718. 10.1016/j.bpobgyn.2004.05.002
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Amato, P, Simpson, JL. (2004). The genetics of polycystic ovary syndrome .
18(5 SPEC. ISS.), 707-718. 10.1016/j.bpobgyn.2004.05.002
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cited authors
Amato, P; Simpson, JL
fiu authors
Leigh Simpson, Joe
abstract
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder. There is evidence for a genetic component in PCOS based on familial clustering of cases. The majority of the evidence supports an autosomal dominant form of inheritance. Steroidogenesis has been shown to be upregulated in PCOS theca cells, suggesting that the genetic abnormality in PCOS affects signal transduction pathways controlling the expression of a family of genes. Although a number of candidate genes have been proposed, the putative PCOS gene(s) has yet to be identified. Linkage and association studies implicate a region near the insulin receptor gene at chr 19p13.3. New genetic approaches, such as microarray technology, hold promise for elucidation of the pathophysiology underlying PCOS. © 2004 Elsevier Ltd. All rights reserved.
publication date
January 1, 2004
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Digital Object Identifier (DOI)
https://doi.org/10.1016/j.bpobgyn.2004.05.002
Additional Document Info
start page
707
end page
718
volume
18
issue
5 SPEC. ISS.