Levels of dopamine and noradrenaline in the developing retina - Effect of light deprivation Article

cited authors

  • Shelke, RRJ; Lakshmana, MK; Ramamohan, Y; Raju, TR

fiu authors

abstract

  • The effect of light deprivation on the levels of dopamine and noradrenaline was studied in the developing rat retina. These transmitters were estimated in three groups of rats: (i) cycling light reared; (ii) dark reared since birth; and (iii) dark reared since birth, but exposed to cycling light for 1 day prior to the estimation of catecholamines. Our results show that (1) there is a progressive decrease in the levels of dopamine and noradrenaline in the cycling light and dark reared rats during postnatal development; (2) dark rearing further reduces the content of dopamine and noradrenaline; and (3) restoration of physiological (light) stimulus in the dark-reared rats during the early postnatal period results in the recovery of noradrenaline to a greater extent than that of dopamine. This study demonstrates a progressive decrease in the plasticity of dopaminergic system during retinal development, while such a decrease is not apparent in the noradrenergic system.

publication date

  • July 31, 1997

Digital Object Identifier (DOI)

start page

  • 139

end page

  • 143

volume

  • 15

issue

  • 1