Background. Children and adolescents frequently have symptoms of anxiety. In addition, anxiety disorders are some of the most frequent psychiatric disorders in this age group. Methods. We used computerized literature searches (MEDLINE and PSYCHLIT) to identify clinical, research, and review articles on this subject. Various journals and textbooks from the psychiatric, medical, and psychology literature were accessed. Results. This review includes findings on the epidemiology, developmentally normal anxiety, clinical presentations, course and outcome, and treatment interventions. Conclusions. Pediatricians and family practitioners should be familiar with the spectrum of anxiety in children and adolescents. Guidelines for referral to a mental health practitioner are reviewed.