The Gender-Specific Aspects of Lung Cancer Book Chapter

cited authors

  • Toonkel, RL; Powell, CA

fiu authors


  • Cigarette smoking remains the leading cause of lung cancer death and of cancer death in women of the world. While it is not yet clear if women are more susceptible to lung cancer, current evidence does suggest that women with lung cancer have an improved prognosis compared to men with similar cigarette smoke exposure. Potential explanations for observed gender disparities in lung cancer include environmental exposures, molecular genetic factors, and hormonal differences. The gap between male and female smoking prevalence is narrowing and we are likely to see the incidence and death rates from lung cancer in women begin to approach those in men. As research continues to be directed towards understanding gender-specific aspects of lung cancer susceptibility and prognosis, advocacy for public policy initiatives will help prevent and reduce smoking prevalence in girls and women. Exposure to environmental pollutants can be remediated, which is a strategy that may be helpful in lowering the incidence of lung cancer in never-smoking women in developing countries. © 2010 Elsevier Inc. All rights reserved.

publication date

  • December 1, 2010

Digital Object Identifier (DOI)

start page

  • 260

end page

  • 269