MicroRNA regulation of the major drug-metabolizing enzymes and related transcription factors. Article

Dluzen, Douglas F, Lazarus, Philip. (2015). MicroRNA regulation of the major drug-metabolizing enzymes and related transcription factors. . 47(3), 320-334. 10.3109/03602532.2015.1076438

cited authors

  • Dluzen, Douglas F; Lazarus, Philip

fiu authors

abstract

  • Identifying novel mechanisms contributing to patient variability of drug response is a major goal of personalized medicine. Epigenetic regulation of gene expression by microRNA (miRNA) impacts a broad range of cellular processes, but knowledge of its regulation of drug-metabolizing enzymes (DMEs) is more limited. This review provides an introduction to miRNA and their functionality and summarizes known miRNA regulation of DME families, including the cytochrome P450s, UDP-glucuronoslytransferases, glutathione-S-transferases, sulfotransferases and aldo-keto reductases, and the transcription factors known to be involved in DME regulation.

publication date

  • August 20, 2015

keywords

  • Aldo-Keto Reductases
  • Animals
  • Biotransformation
  • Cytochrome P-450 Enzyme System
  • Epigenesis, Genetic
  • Gene Expression Regulation, Enzymologic
  • Glucuronosyltransferase
  • Glutathione Transferase
  • Humans
  • MicroRNAs
  • Sulfotransferases
  • Transcription Factors

Digital Object Identifier (DOI)

Medium

  • Print-Electronic

start page

  • 320

end page

  • 334

volume

  • 47

issue

  • 3