No Association Between Vitamin D Intake, VDR Polymorphisms, and Colorectal Cancer in a Population-Based Case-Control Study. Other Scholarly Work

Ashmore, Joseph H, Gallagher, Carla J, Lesko, Samuel M et al. (2015). No Association Between Vitamin D Intake, VDR Polymorphisms, and Colorectal Cancer in a Population-Based Case-Control Study. . 24(10), 1635-1637. 10.1158/1055-9965.epi-15-0284

cited authors

  • Ashmore, Joseph H; Gallagher, Carla J; Lesko, Samuel M; Muscat, Joshua E; Hartman, Terryl J; Lazarus, Philip

fiu authors

abstract

  • Background

    Epidemiologic evidence indicates that greater intakes of vitamin D may decrease the risk of colorectal cancer. Variants in the vitamin D receptor (VDR) gene have the potential to modify associations between vitamin D intake and colorectal cancer.

    Methods

    Associations between intakes of vitamin D and colorectal cancer were studied in a large case-control study conducted in central and northeastern Pennsylvania including 1,012 cases with histologically confirmed colorectal cancer and 1,080 population-based controls. Associations between 35 tagSNPs encompassing the VDR gene and risk for colorectal cancer as well as gene-diet associations were also assessed among a subset of the population (770 controls, 710 cases).

    Results

    No significant trends were observed between vitamin D intake and colorectal cancer risk. After adjustment for multiple comparisons, none of the SNPs or haplotypes within the VDR gene were associated with colorectal cancer. There were also no interactions between dietary factors and variants in the entire VDR gene.

    Conclusions

    Overall, results from this study suggest that vitamin D intake and variants in the VDR gene have little effect on risk for colorectal cancer.

    Impact

    Increasing vitamin D intake from the diet may not result in decreasing the incidence of colorectal cancer.

publication date

  • October 1, 2015

keywords

  • Aged
  • Colorectal Neoplasms
  • DNA, Neoplasm
  • Dose-Response Relationship, Drug
  • Female
  • Follow-Up Studies
  • Gene Frequency
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Pennsylvania
  • Polymorphism, Genetic
  • Population Surveillance
  • Receptors, Calcitriol
  • Retrospective Studies
  • Risk Factors
  • Vitamin D
  • Vitamins

Digital Object Identifier (DOI)

Medium

  • Print-Electronic

start page

  • 1635

end page

  • 1637

volume

  • 24

issue

  • 10