History of diabetes and risk of head and neck cancer: a pooled analysis from the international head and neck cancer epidemiology consortium. Article

Stott-Miller, Marni, Chen, Chu, Chuang, Shu-Chun et al. (2012). History of diabetes and risk of head and neck cancer: a pooled analysis from the international head and neck cancer epidemiology consortium. . 21(2), 294-304. 10.1158/1055-9965.epi-11-0590

cited authors

  • Stott-Miller, Marni; Chen, Chu; Chuang, Shu-Chun; Lee, Yuan-Chin Amy; Boccia, Stefania; Brenner, Hermann; Cadoni, Gabriela; Dal Maso, Luigino; La Vecchia, Carlo; Lazarus, Philip; Levi, Fabio; Matsuo, Keitaro; Morgenstern, Hal; Müller, Heiko; Muscat, Joshua; Olshan, Andrew F; Purdue, Mark P; Serraino, Diego; Vaughan, Thomas L; Zhang, Zuo-Feng; Boffetta, Paolo; Hashibe, Mia; Schwartz, Stephen M

fiu authors

abstract

  • Background

    A history of diabetes is associated with an increased risk of several types of cancers. Whether diabetes is a risk factor for head and neck cancer (HNC) has received little attention.

    Methods

    We pooled data from 12 case-control studies including 6,448 cases and 13,747 controls, and estimated OR and 95% CI for the associations between diabetes and HNC, adjusted for age, education level, sex, race/ethnicity, study center, cigarette smoking, alcohol use, and body mass index.

    Results

    We observed a weak association between diabetes and the incidence of HNC overall (OR, 1.09; 95% CI: 0.95-1.24). However, we observed a modest association among never smokers (OR, 1.59; 95% CI: 1.22-2.07), and no association among ever smokers (OR, 0.96; 95% CI: 0.83-1.11); likelihood ratio test for interaction P = 0.001.

    Conclusion

    A history of diabetes was weakly associated with HNC overall, but we observed evidence of effect modification by smoking status, with a positive association among those who never smoked cigarettes.

    Impact

    This study suggests that glucose metabolism abnormalities may be a HNC risk factor in subgroups of the population. Prospective studies incorporating biomarkers are needed to improve our understanding of the relationship between diabetes and HNC risk, possibly providing new strategies in the prevention of HNC.

publication date

  • February 1, 2012

keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Diabetes Complications
  • Diabetes Mellitus
  • Europe
  • Female
  • Head and Neck Neoplasms
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Risk Factors
  • United States
  • Young Adult

Digital Object Identifier (DOI)

Medium

  • Print-Electronic

start page

  • 294

end page

  • 304

volume

  • 21

issue

  • 2