Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks. Article

Jones, Nathan R, Ashmore, Joseph H, Lee, Sang Y et al. (2015). Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks. . 7(4), 2386-2396. 10.3390/cancers7040898

cited authors

  • Jones, Nathan R; Ashmore, Joseph H; Lee, Sang Y; Richie, John P; Lazarus, Philip; Muscat, Joshua E

fiu authors

abstract

  • Background

    Polymorphisms in the hemochromatosis (HFE) gene are associated with excessive iron absorption from the diet, and pro-oxidant effects of iron accumulation are thought to be a risk factor for several types of cancer.

    Methods

    The C282Y (rs1800562) and H63D (rs1799945) polymorphisms were genotyped in 301 oral cancer cases and 437 controls and analyzed in relation to oral cancer risk, and serum iron biomarker levels from a subset of 130 subjects.

    Results

    Individuals with the C282Y allele had lower total iron binding capacity (TIBC) (321.2 ± 37.2 µg/dL vs. 397.7 ± 89.0 µg/dL, p = 0.007) and higher percent transferrin saturation (22.0 ± 8.7 vs. 35.6 ± 22.9, p = 0.023) than wild type individuals. Iron and ferritin levels approached significantly higher levels for the C282Y allele (p = 0.0632 and p = 0.0588, respectively).

    Conclusions

    Iron biomarker levels were elevated by the C282Y allele, but neither (rs1800562) nor (rs1799945) was associated with oral cancer risk in blacks and whites.

publication date

  • December 9, 2015

Digital Object Identifier (DOI)

Medium

  • Electronic

start page

  • 2386

end page

  • 2396

volume

  • 7

issue

  • 4