Meat-related compounds and colorectal cancer risk by anatomical subsite. Other Scholarly Work

Miller, Paige E, Lazarus, Philip, Lesko, Samuel M et al. (2013). Meat-related compounds and colorectal cancer risk by anatomical subsite. . 65(2), 202-226. 10.1080/01635581.2013.756534

cited authors

  • Miller, Paige E; Lazarus, Philip; Lesko, Samuel M; Cross, Amanda J; Sinha, Rashmi; Laio, Jason; Zhu, Jay; Harper, Gregory; Muscat, Joshua E; Hartman, Terryl J

fiu authors


  • Since meat may be involved in the etiology of colorectal cancer, associations between meat-related compounds were examined to elucidate underlying mechanisms in a population-based case-control study. Participants (989 cases/1,033 healthy controls) completed a food frequency questionnaire with a meat-specific module. Multivariable logistic regression was used to examine associations between meat variables and colorectal cancer; polytomous logistic regression was used for subsite-specific analyses. The following significant positive associations were observed for meat-related compounds: 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and colorectal, distal colon, and rectal tumors; 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and colorectal and colon cancer tumors; nitrites/nitrates and proximal colon cancer; 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and rectal cancer; and benzo[a]pyrene and rectal cancer (P-trends < 0.05). For analyses by meat type, cooking method, and doneness preference, positive associations between red processed meat and proximal colon cancer and pan-fried red meat and colorectal cancer were found (P-trends < 0.05). Inverse associations were observed between unprocessed poultry and colorectal, colon, proximal colon, and rectal tumors; grilled/barbequed poultry and proximal colon cancer; and well-done/charred poultry and colorectal, colon, and proximal colon tumors (P-trends < 0.05). HCAs, PAHs, nitrites, and nitrates may be involved in colorectal cancer etiology. Further examination into the unexpected inverse associations between poultry and colorectal cancer is warranted.

publication date

  • January 1, 2013


  • Aged
  • Animals
  • Benzo(a)pyrene
  • Case-Control Studies
  • Colonic Neoplasms
  • Colorectal Neoplasms
  • Cooking
  • Feeding Behavior
  • Female
  • Humans
  • Imidazoles
  • Logistic Models
  • Male
  • Meat
  • Meat Products
  • Middle Aged
  • Nitrates
  • Nitrites
  • Pennsylvania
  • Poultry
  • Quinoxalines
  • Rectal Neoplasms
  • Risk Factors
  • Surveys and Questionnaires

Digital Object Identifier (DOI)


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start page

  • 202

end page

  • 226


  • 65


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