Association of metabolic gene polymorphisms with tobacco consumption in healthy controls. Other Scholarly Work

Smits, Kim M, Benhamou, Simone, Garte, Seymour et al. (2004). Association of metabolic gene polymorphisms with tobacco consumption in healthy controls. . 110(2), 266-270. 10.1002/ijc.20114

cited authors

  • Smits, Kim M; Benhamou, Simone; Garte, Seymour; Weijenberg, Matty P; Alamanos, Yannis; Ambrosone, Christine; Autrup, Herman; Autrup, Judith L; Baranova, Helena; Bathum, Lisa; Boffetta, Paolo; Bouchardy, C; Brockmoller, Jurgen; Butkiewicz, Dorota; Cascorbi, Ingolf; Clapper, Margie L; Coutelle, Christiane; Daly, Ann K; Muzi, Giacomo; Dolzan, Vita; Duzhak, Tatyana G; Farker, Katrin; Golka, Klaus; Haugen, Aage; Hein, David W; Hildesheim, Allan; Hirvonen, Ari; Hsieh, Ling L; Ingelman-Sundberg, Magnus; Kalina, Ivan; Kang, Daehee; Katoh, Takahiko; Kihara, Masahiro; Ono-Kihara, Masako; Kim, Heon; Kiyohara, Chikako; Kremers, Pierre; Lazarus, Philip; Le Marchand, Loic; Lechner, Maria C; London, Stephanie; Manni, Johannes J; Maugard, Christine M; Morgan, Gareth J; Morita, Shunji; Nazar-Stewart, Valle; Kristensen, Vessela Nedelcheva; Oda, Yoshio; Parl, Fritz F; Peters, Wilbert HM; Rannug, Agneta; Rebbeck, Timothy; Pinto, Luis F Ribeiro; Risch, Angela; Romkes, Marjorie; Salagovic, Jan; Schoket, Bernadette; Seidegard, Janeric; Shields, Peter G; Sim, Edith; Sinnett, Daniel; Strange, Richard C; Stucker, Isabelle; Sugimura, Haruhiko; To-Figueras, Jordi; Vineis, Paolo; Yu, Mimi C; Zheng, Wei; Pedotti, Paola; Taioli, Emanuela

fiu authors

abstract

  • Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYP1A1, GSTM1, GSTT1, NAT2 and GSTP1. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected.

publication date

  • June 1, 2004

keywords

  • Arylamine N-Acetyltransferase
  • Genetic Predisposition to Disease
  • Glutathione S-Transferase pi
  • Glutathione Transferase
  • Humans
  • Isoenzymes
  • Polymorphism, Genetic
  • Smoking

Digital Object Identifier (DOI)

Medium

  • Print

start page

  • 266

end page

  • 270

volume

  • 110

issue

  • 2