Identification and partial characterization of the c-jun oncogene in Xenopus laevis. Other Scholarly Work

Lazarus, P, Calcagnotto, A. (1994). Identification and partial characterization of the c-jun oncogene in Xenopus laevis. . 86(2), 201-208. 10.1016/0304-3835(94)90079-5

cited authors

  • Lazarus, P; Calcagnotto, A

fiu authors

abstract

  • Sequencing analysis of a 275-nt cDNA fragment encoding the DNA-binding region at the carboxyl terminal of the Xenopus c-jun protein product shows that this region exhibits 77-79% nucleotide homology and 93% amino acid homology with the DNA-binding region of mouse and human c-jun, and contains an intact leucine zipper motif and a basic DNA-binding region. Xenopus c-jun mRNA is induced in quiescent Xenopus A6 kidney cells by 12-O-tetradecanoylphorbol-13-acetate, PDGF and cycloheximide. This 'immediate early' response suggests that Xenopus c-jun may be similar in both structure and function to that observed for its mammalian counterpart.

publication date

  • November 1, 1994

keywords

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Cell Line
  • Genes, jun
  • Kidney
  • Leucine Zippers
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Sequence Homology, Nucleic Acid
  • Xenopus laevis

Digital Object Identifier (DOI)

Medium

  • Print

start page

  • 201

end page

  • 208

volume

  • 86

issue

  • 2