Effects of menthol on tobacco smoke exposure, nicotine dependence, and NNAL glucuronidation. Other Scholarly Work

Muscat, Joshua E, Chen, Gang, Knipe, Ashley et al. (2009). Effects of menthol on tobacco smoke exposure, nicotine dependence, and NNAL glucuronidation. . 18(1), 35-41. 10.1158/1055-9965.epi-08-0744

cited authors

  • Muscat, Joshua E; Chen, Gang; Knipe, Ashley; Stellman, Steven D; Lazarus, Philip; Richie, John P

fiu authors

abstract

  • Menthol is a controversial cigarette additive because its physiologic or pharmacologic effects may possibly increase the risk for cancer and its targeted market is the Black community. In a community-based cross-sectional study on 525 Black and White volunteers, we compared levels of urinary and plasma cotinine, plasma thiocyanate, urinary 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanol (NNAL), and its detoxified form (NNAL-Gluc) between menthol and nonmenthol smokers. In regression models that adjusted for daily cigarette intake, no significant differences were observed in the concentration of these biomarkers by menthol status in both races. There was no significant association between high Fagerstrom nicotine dependence scores and the use of menthol cigarettes (odds ratio, 1.1; 95% confidence interval, 0.6-2.0), but an increased risk was observed with smoking a cigarette soon (

publication date

  • January 1, 2009

keywords

  • Biomarkers
  • Blacks
  • Chi-Square Distribution
  • Cotinine
  • Cross-Sectional Studies
  • Female
  • Glucuronates
  • Humans
  • Male
  • Menthol
  • Nitrosamines
  • Regression Analysis
  • Thiocyanates
  • Tobacco Smoke Pollution
  • Tobacco Use Disorder
  • Whites

Digital Object Identifier (DOI)

Medium

  • Print

start page

  • 35

end page

  • 41

volume

  • 18

issue

  • 1