Aspirin and NSAID use and lung cancer risk: a pooled analysis in the International Lung Cancer Consortium (ILCCO). Other Scholarly Work

McCormack, Valerie A, Hung, Rayjean J, Brenner, Darren R et al. (2011). Aspirin and NSAID use and lung cancer risk: a pooled analysis in the International Lung Cancer Consortium (ILCCO). . 22(12), 1709-1720. 10.1007/s10552-011-9847-z

cited authors

  • McCormack, Valerie A; Hung, Rayjean J; Brenner, Darren R; Bickeböller, Heike; Rosenberger, Albert; Muscat, Joshua E; Lazarus, Philip; Tjønneland, Anne; Friis, Søren; Christiani, David C; Chun, Eun-Mi; Le Marchand, Loic; Rennert, Gad; Rennert, Hedy S; Andrew, Angeline S; Orlow, Irene; Park, Bernard; Boffetta, Paolo; Duell, Eric J

fiu authors

abstract

  • Purpose

    To investigate the hypothesis that non-steroidal anti-inflammatory drugs (NSAIDs) lower lung cancer risk.

    Methods

    We analysed pooled individual-level data from seven case-control and one cohort study in the International Lung Cancer Consortium (ILCCO). Relative risks for lung cancer associated with self-reported history of aspirin and other NSAID use were estimated within individual studies using logistic regression or proportional hazards models, adjusted for packyears of smoking, age, calendar period, ethnicity and education and were combined using random effects meta-analysis.

    Results

    A total of 4,309 lung cancer cases (mean age at diagnosis 65 years, 45% adenocarcinoma and 22% squamous-cell carcinoma) and 58,301 non-cases/controls were included. Amongst controls, 34% had used NSAIDs in the past (81% of them used aspirin). After adjustment for negative confounding by smoking, ever-NSAID use (affirmative answer to the study-specific question on NSAID use) was associated with a 26% reduction (95% confidence interval 8 to 41%) in lung cancer risk in men, but not in women (3% increase (-11% to 30%)). In men, the association was stronger in current and former smokers, and for squamous-cell carcinoma than for adenocarcinomas, but there was no trend with duration of use. No differences were found in the effects on lung cancer risk of aspirin and non-aspirin NSAIDs.

    Conclusions

    Evidence from ILCCO suggests that NSAID use in men confers a modest protection for lung cancer, especially amongst ever-smokers. Additional investigation is needed regarding the possible effects of age, duration, dose and type of NSAID and whether effect modification by smoking status or sex exists.

publication date

  • December 1, 2011

keywords

  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal
  • Aspirin
  • Female
  • Humans
  • Lung Neoplasms
  • Male
  • Middle Aged
  • Risk Factors
  • Surveys and Questionnaires

Digital Object Identifier (DOI)

Medium

  • Print-Electronic

start page

  • 1709

end page

  • 1720

volume

  • 22

issue

  • 12