Gene-gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer. Article

Rosenberger, Albert, Muttray, Nils, Hung, Rayjean J et al. (2022). Gene-gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer. . 27(1), 14. 10.1186/s40001-022-00638-7

cited authors

  • Rosenberger, Albert; Muttray, Nils; Hung, Rayjean J; Christiani, David C; Caporaso, Neil E; Liu, Geoffrey; Bojesen, Stig E; Le Marchand, Loic; Albanes, Demetrios; Aldrich, Melinda C; Tardon, Adonina; Fernández-Tardón, Guillermo; Rennert, Gad; Field, John K; Davies, Michael PA; Liloglou, Triantafillos; Kiemeney, Lambertus A; Lazarus, Philip; Wendel, Bernadette; Haugen, Aage; Zienolddiny, Shanbeh; Lam, Stephen; Schabath, Matthew B; Andrew, Angeline S; Duell, Eric J; Arnold, Susanne M; Goodman, Gary E; Chen, Chu; Doherty, Jennifer A; Taylor, Fiona; Cox, Angela; Woll, Penella J; Risch, Angela; Muley, Thomas R; Johansson, Mikael; Brennan, Paul; Landi, Maria Teresa; Shete, Sanjay S; Amos, Christopher I; Bickeböller, Heike; INTEGRAL-ILCCO Consortium

fiu authors

abstract

  • Background

    Aberrant Wnt signalling, regulating cell development and stemness, influences the development of many cancer types. The Aryl hydrocarbon receptor (AhR) mediates tumorigenesis of environmental pollutants. Complex interaction patterns of genes assigned to AhR/Wnt-signalling were recently associated with lung cancer susceptibility.

    Aim

    To assess the association and predictive ability of AhR/Wnt-genes with lung cancer in cases and controls of European descent.

    Methods

    Odds ratios (OR) were estimated for genomic variants assigned to the Wnt agonist and the antagonistic genes DKK2, DKK3, DKK4, FRZB, SFRP4 and Axin2. Logistic regression models with variable selection were trained, validated and tested to predict lung cancer, at which other previously identified SNPs that have been robustly associated with lung cancer risk could also enter the model. Furthermore, decision trees were created to investigate variant × variant interaction. All analyses were performed for overall lung cancer and for subgroups.

    Results

    No genome-wide significant association of AhR/Wnt-genes with overall lung cancer was observed, but within the subgroups of ever smokers (e.g., maker rs2722278 SFRP4; OR  = 1.20; 95% CI 1.13-1.27; p  = 5.6 × 10-10) and never smokers (e.g., maker rs1133683 Axin2; OR  = 1.27; 95% CI 1.19-1.35; p  = 1.0 × 10-12). Although predictability is poor, AhR/Wnt-variants are unexpectedly overrepresented in optimized prediction scores for overall lung cancer and for small cell lung cancer. Remarkably, the score for never-smokers contained solely two AhR/Wnt-variants. The optimal decision tree for never smokers consists of 7 AhR/Wnt-variants and only two lung cancer variants.

    Conclusions

    The role of variants belonging to Wnt/AhR-pathways in lung cancer susceptibility may be underrated in main-effects association analysis. Complex interaction patterns in individuals of European descent have moderate predictive capacity for lung cancer or subgroups thereof, especially in never smokers.

publication date

  • January 31, 2022

keywords

  • Basic Helix-Loop-Helix Transcription Factors
  • Female
  • Gene Expression Regulation, Neoplastic
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • INTEGRAL-ILCCO Consortium
  • Lung Neoplasms
  • Male
  • Middle Aged
  • RNA, Neoplasm
  • Receptors, Aryl Hydrocarbon
  • Wnt Signaling Pathway

Digital Object Identifier (DOI)

Medium

  • Electronic

start page

  • 14

volume

  • 27

issue

  • 1