Emerging nanotechnology and targeted drug delivery approaches have come up with alternative delivery carriers for better therapeutics. Nanogels are also known as hydrogel nanoparticles that have gained significant attention as a nanocarrier system. The brain, the most crucial and sensitive organ of the human body, is well known to be protected by a strong blood brain barrier (BBB), which shields it from any foreign substances. Numerous drugs are unable to cross this strong barrier and thus restricts the use of newly developed drugs to be utilized for brain disease. The diverse spectrum of nanogel-based drug delivery systems have shown promising results in transporting many therapeutics and bioactives across the BBB as well as drug delivery for various neurological disorders. The present chapter is an attempt to highlight the various nanogel systems exploited for brain drug delivery.