Anopheles midgut FREP1 mediates plasmodium invasion Article

cited authors

  • Zhang, G; Niu, G; Franca, CM; Dong, Y; Wang, X; Butler, NS; Dimopoulos, G; Li, J

abstract

  • Background: The molecular mechanisms of Plasmodium invasion in mosquito midguts are not well understood. Results: The mosquito midgut peritrophic matrix protein FREP1 binds Plasmodia. Blocking parasite-FREP1 interactions or ablating FREP1 expression reduced P. falciparum infection in mosquitoes. Conclusion: FREP1 functions as a critical host factor that mediates Plasmodium invasion in mosquito midguts. Significance: Targeting FREP1 may inhibit Plasmodium transmission to mosquitoes and the spread of malaria.

publication date

  • July 3, 2015

Digital Object Identifier (DOI)

start page

  • 16490

end page

  • 16501

volume

  • 290

issue

  • 27